A role for the retinoblastoma protein as a regulator of mouse osteoblast cell adhesion: implications for osteogenesis and osteosarcoma formation.

The retinoblastoma protein (pRb) is a cell cycle regulator inactivated in most human cancers.Loss of pRb function results from mutations in the gene coding for pRb or for any of its upstream regulators.Although pRb is predominantly known as a cell cycle repressor, our data point to additional pRb functions in cell adhesion.Our data show that pRb re

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Routing Protocol for Intelligent Unmanned Cluster Network Based on Node Energy Consumption and Mobility Optimization

Intelligent unmanned clusters have played a crucial role in military reconnaissance, disaster rescue, border patrol, and other domains.Nevertheless, due to factors such as multipath propagation, electromagnetic interference, and frequency band congestion in high dynamic scenarios, unmanned cluster networks experience frequent topology changes and s

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An atlas of GPCRs in dopamine neurons: Identification of the free fatty acid receptor 4 as a regulator of food and water intake

Summary: Midbrain dopaminergic neurons (DANs) are subject to extensive metabotropic regulation, but the repertoire of G protein-coupled receptors (GPCRs) present in these neurons has not been mapped.Here, we isolate DANs from Dat-eGFP mice to generate a 125 GPCR atlas by unbiased qPCR array expression analysis of 377 GPCRs.Combined with data mining

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